Difference between revisions of "User:Sarah.Minucci"

Latest revision as of 12:38, 3 August 2015

Research Topic

Mentor: Dr. Stephen Merrill
Working title: The relationship between leptin and inflammation determines critical points in excess nutrition

Abstract: Research shows a significant relationship between leptin, a hormone involved in energy intake and expenditure, and inflammation in adipose tissue, the main depot of fat storage. These findings suggest an important factor in the drastic weight increase associated with obesity: a cycle of inflammation due to increases in leptin levels. This inflammation and subsequent weight gain, as well as difficulty in losing weight, could help to explain why lifestyle changes are often not enough to mediate obesity or keep weight off long-term. The pleiotropic role of leptin not only points to its influence in obesity, but also its comorbidities, including type 2 diabetes mellitus, metabolic syndrome, and heart disease, as well as in general immune system dysfunction. In fact, leptin seems to be a crucial factor in the prevalence of autoimmune diseases in women, especially women with greater amounts of adipose tissue. Through construction of a mathematical model of the relationships between leptin, inflammation, and adipose tissue, we can better understand the role of leptin in adipose tissue inflammation, specifically in women. Insight into these relationships is necessary in better treating obesity, understanding the sexual dimorphism of immune system dysfunction, and determining risk for autoimmune diseases and obesity-related health complications.

Milestones & Goals

Week 1

Verification of leptin production and relation to amount of fat

3-5 pages of research paper
Key research topics:
- What is the relationship between fat and leptin?
- Is it linear or exponential or something else?
- What are the units involved?

Weeks 2-5

How are leptin levels related to amount of inflammation?

3-4 pages of research paper
Key research topics:
- Look for inflammatory molecules that are measured regularly that will help to gauge inflammation levels
- A biomarker to quantify inflammation levels

Weeks 5-10

Choose one of the following directions and develop its relationship with leptin, inflammation & autoimmunity

Diabetes
Heart Disease
Drug-induced autoimmunity
Thyroid
Sexual dimorphism of leptin levels

Research Log

Week 1 / / 6.1-5

Introduction to differential equations
Compiled research focus & milestones with Dr. Merrill
Became familiar with RefWorks & library resources
Became familiar with MatLab
Read literature about my topic and found answers to the following questions via databases such as Medline and Web of Science
- What is the rate of release of adipokines from fat?
- When leptin is released, where does it go and what is its rate of metabolism?
- What are the units involved in the metabolism rate?
- How does leptin relate to fat?
- Is the leptin-fat model linear?
- How is leptin measured?
- Is the leptin-fat relationship related to gender?
Investigated free leptin vs. bound leptin

Week 2 / / 6.8-12

Monday

Condensed research so far into questions answered
Wrote part of research paper
Started researching inflammation and leptin

Tuesday

Researched bound and free leptin
Wrote part of research paper
Researched inflammation
Found research that may point to an exponential relationship between leptin and fat
Met with Dr. Merrill

Wednesday

Focuses: BMI, inflammation
Verified linear relationship between BMI and weight/fat - this could pose some problems for a linear model of leptin and fat
Read articles linking inflammation to leptin (key words: thyroid, TNF, T-cells)

Thursday

Compiled information and wrote several pages of paper about leptin/inflammation/immunity
Met with Dr. Merrill - threw out linear model and opted to try some kind of quadratic model

Friday

Organized wiki page
Wrote about findings on leptin, inflammation, and immunity
Wrote new proposal for mathematical model equations

Week 3 / / 6.15-19

Monday

Finished Friday's paper
Literature search for biomarkers of inflammation
Investigated role of estrogen in obesity, breast cancer and the immune system

Tuesday

Continued investigating biomarkers
Met with Dr. Merrill

Wednesday

Focus: quantifying the relationship between fat and inflammation
Literature on inflammation in fat, sexual dimorphism in fat distribution and leptin levels

Thursday

Created a visual model of a leptin/inflammation feedback loop (solidified our hypothesis)
Responsible Conduct of Research training

Friday

Solidified feedback loop
Met with Dr. Merrill

Week 4 / / 6.22-26

Monday

Played around with equations; fine-tuned
Research on cytokines

Tuesday

Continued working on equations
Met with Dr. Merrill
Tweaked equations
Started final paper

Wednesday

Worked on final paper

Thursday

Worked on final paper and mid-REU presentation

Friday

Met with Dr. Merrill
Worked on presentation and final paper

Week 5 / / 6.29-7.3

Monday

Worked on presentation
Literature research on questions about SAT and measures of inflammation:
- In the literature, how is inflammation described/measured?
- How does VAT produce more inflammation than SAT?
- How does TNF-alpha increase adipocyte apoptosis?

Tuesday

Worked on presentation
Met with Dr. Merrill
Worked on visual representation of equations

Wednesday

Worked on presentation
Literature research on sexual dimorphism information and verification
Visual representation of equations

Thursday

Attended other students' midpoint presentations
Updated wiki
Attended graduate student's Master's thesis presentation

Friday

OFF (Fourth of July holiday)

Week 6 / / 7.6-10

Monday

Research on nonlinear systems & equilibrium points
TikZ
Writing about equations

Tuesday

Writing about equations
RCR training
Evaluated L as a function of SAT

Wednesday

Writing about equations
MATLAB
Met with Dr. Merrill

Thursday

MATLAB simulations

Friday

Updated wiki
MATLAB simulation

Week 7 / / 7.13-17

Monday

Mathematical analysis of cases of SAT values and their relationships with inflammation and leptin

Tuesday

Analysis of cases
Writing for final paper
Read literature about possible applications of the model

Wednesday

Read literature about possible applications of the model
Met with Dr. Merrill
Writing about system of equations
Phase plane analyses of cases
MATLAB simulations of cases

Thursday

Writing about cases
MATLAB simulations of cases

Friday

Writing about cases
Writing: motivation, introduction, research goals

Week 8 / / 7.20-24

Monday

Writing final paper
Reading literature related to potential applications of the model
Making connections between model and its applications
MATLAB simulations

Tuesday

Meeting with Dr. Merrill
Writing final paper
Reading literature and making connections related to potential applications of the model
Compiling references

Wednesday

Writing proofs
Working on poster

Thursday

Writing paper
Working on poster

Friday

Meeting with Dr. Merrill
Working on poster

Week 9 / / 7.27-31

Monday

Poster
Paper

Tuesday

Paper

Wednesday

Writing paper and formatting it for journal submission

Thursday

Formatting for journal
Compiling references

Friday

Formatting for journal
Working on presentation

@@ Line 4: / Line 4: @@
 ==Research Topic==
 '''Mentor: Dr. Stephen Merrill''' <br>
+'''Working title: The relationship between leptin and inflammation determines critical points in excess nutrition''' <br>
 <br>
-I will be researching the influence of leptin in the body, especially regarding fat, inflammation and immunity.  Leptin, a hormone secreted by fat and fatty tissue which has pro-inflammatory effects in the body, provides a link between nutritional intake and the immune system.  Much is still unknown about these connections, and my goal is to create a mathematical model of some aspect of leptin's influence in the body.
+'''Abstract:''' Research shows a significant relationship between leptin, a hormone involved in energy intake and expenditure, and inflammation in adipose tissue, the main depot of fat storage. These findings suggest an important factor in the drastic weight increase associated with obesity: a cycle of inflammation due to increases in leptin levels.  This inflammation and subsequent weight gain, as well as difficulty in losing weight, could help to explain why lifestyle changes are often not enough to mediate obesity or keep weight off long-term.  The pleiotropic role of leptin not only points to its influence in obesity, but also its comorbidities, including type 2 diabetes mellitus, metabolic syndrome, and heart disease, as well as in general immune system dysfunction.  In fact, leptin seems to be a crucial factor in the prevalence of autoimmune diseases in women, especially women with greater amounts of adipose tissue.  Through construction of a mathematical model of the relationships between leptin, inflammation, and adipose tissue, we can better understand the role of leptin in adipose tissue inflammation, specifically in women.  Insight into these relationships is necessary in better treating obesity, understanding the sexual dimorphism of immune system dysfunction, and determining risk for autoimmune diseases and obesity-related health complications.
+<br>
+<br>
 ==Milestones & Goals==
 ===Week 1===
@@ Line 136: / Line 139: @@
 *OFF (Fourth of July holiday)
-<!--
 ===Week 6 / / 7.6-10===
 '''Monday'''
-*
+*Research on nonlinear systems & equilibrium points
+*TikZ
+*Writing about equations
 '''Tuesday'''
-*
+*Writing about equations
+*RCR training
+*Evaluated L as a function of SAT
 '''Wednesday'''
-*
+*Writing about equations
+*MATLAB
+*Met with Dr. Merrill
 '''Thursday'''
-*
+*MATLAB simulations
 '''Friday'''
-*
+*Updated wiki
+*MATLAB simulation
 ===Week 7 / / 7.13-17===
 '''Monday'''
-*
+*Mathematical analysis of cases of SAT values and their relationships with inflammation and leptin
 '''Tuesday'''
-*
+*Analysis of cases
+*Writing for final paper
+*Read literature about possible applications of the model
 '''Wednesday'''
-*
+*Read literature about possible applications of the model
+*Met with Dr. Merrill
+*Writing about system of equations
+*Phase plane analyses of cases
+*MATLAB simulations of cases
 '''Thursday'''
-*
+*Writing about cases
+*MATLAB simulations of cases
 '''Friday'''
-*
+*Writing about cases
+*Writing: motivation, introduction, research goals
 ===Week 8 / / 7.20-24===
 '''Monday'''
-*
+*Writing final paper
+*Reading literature related to potential applications of the model
+*Making connections between model and its applications
+*MATLAB simulations
 '''Tuesday'''
-*
+*Meeting with Dr. Merrill
+*Writing final paper
+*Reading literature and making connections related to potential applications of the model
+*Compiling references
 '''Wednesday'''
-*
+*Writing proofs
+*Working on poster
 '''Thursday'''
-*
+*Writing paper
+*Working on poster
 '''Friday'''
-*
+*Meeting with Dr. Merrill
+*Working on poster
 ===Week 9 / / 7.27-31===
 '''Monday'''
-*
+*Poster
+*Paper
 '''Tuesday'''
-*
+*Paper
 '''Wednesday'''
-*
+*Writing paper and formatting it for journal submission
 '''Thursday'''
-*
+*Formatting for journal
+*Compiling references
 '''Friday'''
-*
+*Formatting for journal
+*Working on presentation
+<!--
 ===Week 10 / / 8.3-7===
 '''Monday'''

Difference between revisions of "User:Sarah.Minucci"

Latest revision as of 12:38, 3 August 2015

Contents

Research Topic

Milestones & Goals

Week 1

Weeks 2-5

Weeks 5-10

Research Log

Week 1 / / 6.1-5

Week 2 / / 6.8-12

Week 3 / / 6.15-19

Week 4 / / 6.22-26

Week 5 / / 6.29-7.3

Week 6 / / 7.6-10

Week 7 / / 7.13-17

Week 8 / / 7.20-24

Week 9 / / 7.27-31

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