Difference between revisions of "User:Sarah.Minucci"
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Revision as of 14:45, 12 June 2015
Research Topic
Mentor: Dr. Stephen Merrill
I will be researching the influence of leptin in the body, especially regarding fat, inflammation and immunity. Leptin, a hormone secreted by fat and fatty tissue which has pro-inflammatory effects in the body, provides a link between nutritional intake and the immune system. Much is still unknown about these connections, and my goal is to create a mathematical model of some aspect of leptin's influence in the body.
Milestones & Goals
Week 1
Verification of leptin production and relation to amount of fat
- 3-5 pages of research paper
- Key research topics:
- What is the relationship between fat and leptin?
- Is it linear or exponential or something else?
- What are the units involved?
Weeks 2-5
How are leptin levels related to amount of inflammation?
- 3-4 pages of research paper
- Key research topics:
- Look for inflammatory molecules that are measured regularly that will help to gauge inflammation levels
- A biomarker to quantify inflammation levels
Weeks 5-10
Choose one of the following directions and develop its relationship with leptin, inflammation & autoimmunity
- Diabetes
- Heart Disease
- Drug-induced autoimmunity
- Thyroid
- Sexual dimorphism of leptin levels
Research Log
Week 1 / / 6.1-5
- Introduction to differential equations
- Compiled research focus & milestones with Dr. Merrill
- Became familiar with RefWorks & library resources
- Became familiar with MatLab
- Read literature about my topic and found answers to the following questions via databases such as Medline and Web of Science
- What is the rate of release of adipokines from fat?
- When leptin is released, where does it go and what is its rate of metabolism?
- What are the units involved in the metabolism rate?
- How does leptin relate to fat?
- Is the leptin-fat model linear?
- How is leptin measured?
- Is the leptin-fat relationship related to gender?
- Investigated free leptin vs. bound leptin
Week 2 / / 6.8-12
Monday
- Condensed research so far into questions answered
- Wrote part of research paper
- Started researching inflammation and leptin
Tuesday
- Researched bound and free leptin
- Wrote part of research paper
- Researched inflammation
- Found research that may point to an exponential relationship between leptin and fat
- Met with Dr. Merrill
Wednesday
- Focuses: BMI, inflammation
- Verified linear relationship between BMI and weight/fat - this could pose some problems for a linear model of leptin and fat
- Read articles linking inflammation to leptin (key words: thyroid, TNF, T-cells)
Thursday
- Compiled information about leptin/inflammation/immunity
- Met with Dr. Merrill - threw out linear model and opted to try some kind of quadratic model
Friday
- Organized wiki page
Week 3 / / 6.15-19
Monday
Tuesday
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Week 4 / / 6.22-26
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Week 5 / / 6.29-7.3
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Week 6 / / 7.6-10
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Week 7 / / 7.13-17
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Week 8 / / 7.20-24
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Week 9 / / 7.27-31
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Week 10 / / 8.3-7
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